GLENDALE, AZ – JANUARY 10: ESPN reporter Lou Holtz looks on during the Tostitos BCS National Championship Game between the Oregon Ducks and the Auburn Tigers at University of Phoenix Stadium on January 10, 2011 in Glendale, Arizona. (Photo by Kevin C. Cox/Getty Images)No. 2 Clemson take on Florida State this weekend in a game that could all but cement Clemson’s spot in the ACC Championship game. ESPN analyst and former college football head coach Lou Holtz weighed in on the game – and predicts a big result in the game.On The Crowd’s Line College Football Show with Lou Holtz & Mark May, the two veteran analysts gave their picks. Unsurprisingly, both picked Clemson – and both predicted the Tigers to win big.“I think Florida State has good talent,” Holtz said. “If their offensive line shows up and compete with Clemson’s defensive line, they have a chance but I don’t think it’s gonna happen. Even though it’s at Florida State, and let’s remember this, Florida State is really fighting for a bowl game… I look for Clemson to prevail 38-17.”May predicted the Tigers would win 46-21.WEEK 9 – Lou Holtz and Mark May Breakdown Clemson vs Florida State from The Crowd’s Line on Vimeo.The Tigers have scored 27+ points in every one of their seven wins this season, while allowing seven or fewer four times. Beating them will be a huge ask for the Seminoles.The winner of the Clemson-Florida State game has won the ACC Atlantic Division in each of the last nine seasons.Additionally, the two teams have combined to win each of the last seven ACC Championship Games.